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Charged and ionizable NPs

#1

Metal core: AuMetal coreCoating ligand: HS-(CH2)10-COOHCoating ligand structureSPR maximum: 518-524nm

Soluble: water, MeOH, EtOH
Description:Show
Metal nanoparticles coated with SAMs of carboxylic acid thiols have been used widely for the immobilization of biomolecules. In these applications, the pH of the NP suspension needs to be adjusted slightly above the pKa of the COOH groups in the SAM (ca. 6-8; see J. Am. Chem. Soc. 2006, 128, 15046; 2007, 129, 6664). The negatively charged NPs thus prepared interact attractively with the positively-charged amino acid side chains of proteins or with heme-containing redox enzymes (Biochemistry, 1993, 32, 13771). Toxicity studies (summarized in Small 2008, 1, 26) show that these NPs have very low toxicity against multiple cell types. Recently, Au/COOH nanoparticles have also been used as building blocks for nanoparticle supracrystals (Science 2006, 312, 420; Nano Lett. 2007, 7, 1018) and as components of "patchy" nanoparticle coatings formed on different types of materials by electrostatic interactions (J. Am. Chem. Soc. 2007, 129, 15623; see products Au(+)Ag(-)55 and Ag(+)Ag(-)55 under category "Mixtures of Charged Nanoparticles").
Catalog No.SizeColorDispercityVolumeConcentration
NP CI 001-0755.5 nmred10 %7.5 mL2.4 x 1014 NPs/mL
NP CI 001-1505.5 nmred10 %15 mL2.4 x 1014 NPs/mL
NP CI 002-07512 nmred20 %7.5 mL2.3 x 1013 NPs/mL
NP CI 002-15012 nmred20 %15 mL2.3 x 1013 NPs/mL

#2

Metal core: AgMetal coreCoating ligand: HS-(CH2)10-COOHCoating ligand structureSPR maximum: 420-424nm

Soluble: water, MeOH, EtOH
Description:Show
In addition to all the properties of their Au counterparts (cf. product Au covered by C10COOH), silver nanoparticles are efficient antibacterial agents. While structurally stablefor months, they slowly release Ag+ cations which interact with sulfhydryl groups of proteins (Ann. Pharmacother. 2001, 35, 1255) causing their denaturation (J. Hosp. Infect. 2006, 62, 58; Biomaterials 2004, 25, 1319) and with bacterial DNA impeding its replication. Coatings based on silver particles are currently used in a variety of medical and consumer products including catheters, surgical masks, suture threads, wound creams and dressings, cell phones (Motorola), and recently in FDA approved food packaging. The image above illustrates antibacterial activity (evidenced by the zones of inhibition around NP-coated plastic disks) of the Boutique's Ag/COOH NPs against both Gram positive and Gram negative bacteria.

Catalog No.SizeColorDispercityVolumeConcentration
NP CI 003-0755.5 nmyellow15 %7.5 mL2.4 x 1014 NPs/mL
NP CI 003-1505.5 nmyellow15 %15 mL2.4 x 1014 NPs/mL
NP CI 004-07512 nmyellow20 %7.5 mL2.3 x 1013 NPs/mL
NP CI 004-15012 nmyellow20 %15 mL2.3 x 1013 NPs/mL

#3

Metal core: AuMetal coreCoating ligand: HS-(CH2)11-N-(CH3)3+Coating ligand structureSPR maximum: 518-524nm

Soluble: water and alcohols
Description:Show
These unique nanoparticles were developed at Northwestern University, USA, and used as building blocks for electrostatic self-assembly of nanoparticle suprastructures (Science 2006, 312, 420; Nano Lett. 2007, 7, 1018). They are water soluble and, unlike NPs coated with primary-amine thiols (cf. product Au coated with HS-(CH2)11-NH2) are electrically charged over the entire range of pH's (J. Am. Chem. Soc. 2006, 128, 15046). Owing to their cationic character, they can also be used to immobilize (via physisorption) anionic species such as DNA (J. Am. Chem. Soc. 2001, 123, 7626).

Figure: Nanoparticle (NP) supracrystals composed of 50% Au/COOH NPs (5.5 nm) and 50% Ag/N(CH3)3+ NPs (5.5 nm) prepared using ProChimia's thiols. These AB crystals have an unusual diamond lattice structure (see Science 2006, 312, 420). The bottom row shows macroscopic sphalerite and diamond crystals of the same morphologies. Courtesy of the Grzybowski Lab, Northwestern University, USA.

Catalog No.SizeColorDispercityVolumeConcentration
NP CI 005-0755.5 nmred10 %7.5 mL2.4 x 1014 NPs/mL
NP CI 005-1505.5 nmred10 %15 mL2.4 x 1014 NPs/mL
NP CI 006-07512 nmred20 %7.5 mL2.3 x 1013 NPs/mL
NP CI 006-15012 nmred20 %15 mL2.3 x 1013 NPs/mL

#4

Metal core: AgMetal coreCoating ligand: HS-(CH2)11-N-(CH3)3+Coating ligand structureSPR maximum: 420-424nm

Soluble: water and alcohols
Description:Show
These NPs combine all the properties of product Au coated with HS-(CH2)11-N-(CH3)3+ with the antibacterial properties of the silver core (see description of product Ag coated with HS-(CH2)10-COOH). Silver core also offers some distinct advantages over gold in ultrasensitive surface-enhanced Raman sensing (SERS; Chem. Rev. 1999, 99, 2957).
Catalog No.SizeColorDispercityVolumeConcentration
NP CI 007-0755.5 nmyellow15 %7.5 mL2.4 x 1014 NPs/mL
NP CI 007-1505.5 nmyellow15 %15 mL2.4 x 1014 NPs/mL
NP CI 008-07512 nmyellow20 %7.5 mL2.3 x 1013 NPs/mL
NP CI 008-15012 nmyellow20 %15 mL2.3 x 1013 NPs/mL

#5

Metal core: AuMetal coreCoating ligand: Mixture of nanoparticles with different charged ligands
ratio 1:1, 2:1,..., 9:1Coating ligand structure
SPR maximum: ~518-524nm

Soluble: water
Description:Show

Literature: 
1. Pillai PP, Kowalczyk B, Kandere-Grzybowska K, Borkowska M, Grzybowski BA, "Engineering Gram Selectivity of Mixed-Charge Gold Nanoparticles by Tuning the Balance of Surface Charges"; Angew. Chem. Int. Ed. Engl. 2016; 55(30): 8610-4
2. Pillai PP, Huda S, Kowalczyk B, Grzybowski BA, "Controlled pH Stability and Adjustable Cellular Uptake of Mixed-Charge Nanoparticles"; J. Am. Chem. Soc. 2013; 135: 6392-6395
3. Yan Y, Warren SC, Fuller P, Grzybowski BA, "Chemoelectronic circuits based on metal nanoparticles"; Nat Nanotechnol. 2016 Jul;11(7): 603-8.

Catalog No.SizeColorDispercityVolumeConcentration
NP CI 009-0755.5 nmred15 %7.5 mL2.4 x 1014 NPs/mL
NP CI 009-1505.5 nmred15 %15 mL2.4 x 1014 NPs/mL
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